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Lopressor online, the two-pronged control-sensitivity analysis suggested that CPP and STPP produced significant dose-related responses. No responses were noted in the non-continent, no-drug control. This effect is consistent with the low-dose sensitization paradigm in which the effects of a lower dose are attenuated in a non-controlled manner.
Our study confirms the results of Lofwall et al. (2000, 2002) who demonstrated that the drug-induced increases in STPP are correlated with the increases in CPP. However, this correlation was attenuated in our study, likely because the non-continent, no-drug control condition was also conducted using low-dose drug (see below and ).
The CPP effect is consistent with the results of two study groups that found significant effects of CPP on the PPI non-continent, no-drug control condition (Bertsch et al., 1997; Lofwall 2008). In this study, the three components of PPI—CDP, STPP, and PDI—were tested, effects of CPP were compared to the corresponding PPI component. Both CPP-trained group and the no-drug control showed significant increases in PPI component 1, which indexed the amount of time stimulus remained on the screen, and in component 2, which measured the length of stimulus stimulus. However, CPP-trained group did not show effect on PPI component 2, indicating that the effect of CPP on PPI was not dependent component 1. Interestingly, a group in which the stimulus ran for 100 trials (see below) also shows significant PPI-component 2 effects, consistent with the hypothesis that there might be a decrease in discrimination of the second condition from first c |
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